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Optimal dosing protocols are based on extrapolation rather than controlled human research

Ludtmann MHR, Angelova PR, Horrocks MH, Choi ML, Rodrigues M, Baev AY, Berezhnov AV, Yao Z, Little D, Banushi B, Al-Menhali AS, Ranasinghe RT, Whiten DR, Yapom R, Dolt KS, Devine MJ, Gissen P, Kunath T, Jaganjac M, Pavlov EV, Klenerman D, Abramov AY, Gandhi S (2018) alpha-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinsons disease

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Myostatin is considered to prevent cellular differentiation

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This is the only controlled efficacy study published for ipamorelin, and it was negative