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While mice lacking adipose HSL can achieve near normal rates of TAG hydrolysis, these animals display severely blunted DAG lipase activity, and as a result, DAG accumulates in adipose tissues (44)

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Some modifications concern the antibodys ability to react with the family of FcRs, to avoid mechanical trapping in tissues or the implementation of FcR-mediated signals interfering with the therapeutic process

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Safety profile: Adverse effects are mainly GI, mild to moderate, and transientconsistent with GLP-1 profiles and most commonly involves nausea and constipation