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Demyelination per se is not only a deficit found in cell function, as it may occur naturally as part of the myelin turnover

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doi: 10.1016/0026-0495(75)90040-2

This variability is shaped by a complex interplay of biological and lifestyle factors, including baseline tissue creatine concentrations, muscle fiber type composition, bone remodeling capacity, neuro-energetic status, habitual dietary creatine intake, sex, age, and physical activity level [80]