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This distinction reflects their different target systems, with the propionyl form serving cardiovascular and peripheral muscle applications that require enhanced blood flow, exercise capacity, and support for cardiac energy metabolism

PMID: 29557146

Thus, substantial and mounting evidence supports a direct contributory role of gut microbiota as a participant in CVD pathogenesis, and preclinical studies indicate that the therapeutic targeting of microbial contributors to the TMAO metaorganismal pathway may hold promise as a novel approach for the prevention or treatment of CVD