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Depletion of GSH and overproduction of ROS in the lens of major intrinsic protein (MIP) mutant mice result in increased expression of Atf3 and Ddit3 63
H., Leung, C

This process is important for preventing damage to cells and DNA

Overall, data from STZ, db/db and HFD+STZ models demonstrate that (i) structured exercise training can mitigate DR-like changes at histologic, functional (ERG) and molecular levels, and (ii) direct manipulation of exerkine pathways (apelin, irisin, adiponectin, clusterin, BDNF) modulates pericyte survival, vascular leakage, neovascularization, apoptosis and inflammatory signaling in the diabetic or ischemic retina

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Studies using expression of E.coli -ECS targeted to the poplar chloroplast or cytosol or to the tobacco chloroplast produced increases in leaf glutathione of up to four-fold (Noctor et al., 1996, 1998a
