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Studies such as this one published in PMC highlight the role of malabsorption from mucocutaneous disorders like epidermolysis bullosa can lead to deficiencies that cannot be addressed adequately with oral supplements

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Vitamin B12 supplements are commonly marketed for energy, metabolism, mood, and more

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A structured search strategy was used to identify in vitro, animal, and human studies that assessed vitamin B-12 status, dietary intake, or supplementation, and the gut microbiome using culture-independent techniques