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In mammals, antibodies are classified into five isotypes (IgG, IgM, IgA, IgD, and IgE) based on immunoglobulin structure

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TLR4-mediated recognition of S protein may initiate receptor dependent internalization and explain SARS-CoV-2 infection in patients and cells lacking or deficient in ACE2 expression (Aboudounya and Heads, 2021

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