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Patients with AD initially face reduced episodic memory, which leads to gradually affected extensive cognitive dysfunctions like apraxia, amnesia, and visuospatial deficits (Eramudugolla et al., 2017)

Bruntz et al

Pan JA, Sun Y, Jiang YP, Bott AJ, Jaber N, Dou Z, et al

JPNS 2020, 25 (4), 335343

[DOI] [PubMed] [Google Scholar] 102.Negre-Salvayre A, Auge N, Ayala V, Basaga H, Boada J, Brenke R, et al

Another recent platform is the Exhalation Delivery System (EDS), which employs positive-pressure exhalation to direct formulations deeper into the superior and posterior nasal regions while minimising pulmonary exposure and dosing variability (Palmer et al., 2018