do you gain weight back when you stop semaglutide after BG Medical Center Weight Regain After Stopping Semaglutide

These predispositions reflect biological variance in how your body processes and responds to incretin therapiesnot a guarantee of medication response or outcome

The metabolic improvements track with what you'd expect from this level of weight loss, though the glucagon component may contribute independently to some of these effects

Accessed Dec 2025

It works by mimicking the effects of a hormone called GLP-1, which is naturally produced by the body in response to food intake, and helps to regulate blood sugar levels by increasing insulin secretion, slowing down stomach emptying, and reducing appetite

Some of these are medical, some are purely practical

The study's other senior author is Markus Stoffel, MD, PhD, professor of metabolic diseases at the Institute of Molecular Health Sciences at ETH Zurich in Switzerland