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RECOVER-TLC Background RECOVER-TLC will build on the work of the RECOVER program, which is led by three NIH Institutes: The National Heart, Lung, and Blood Institute (NHLBI)

In T2DM patients, lixisenatide reduced activation in brain areas including the hypothalamus, temporal lobar regions, lateral ventricle, and cortical areas in obese individuals in contrast to lean T2DM individuals, who showed increased activation in the areas [38]

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6 Similarly, as GLP-1RAs significantly reduced the risk of MACE, mortality from CV causes, when compared with placebo, ADA has suggested that these medications should be used in patients with underlying cardiovascular disease

At the same time, more research is ongoing, especially around pancreatic and thyroid cancer risk

GLP-1 agonist users may continue at maintenance doses long-term under medical supervision