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Triple-hormone-receptor agonist retatrutide for obesity - A phase 2 trial

May 22, 2025: Enforcement ended for 503B facilities compounding semaglutide in bulk

This hormone acts on multiple pathways to regulate appetite and food intake

For most GLP-1 receptor agonists, the answer depends on your specific medication and personal routine

Retatrutide activates three metabolic receptors: GLP-1 (appetite suppression and glucose control), GIP (fat metabolism and insulin regulation), and glucagon (energy expenditure and fat oxidation)

A study published in The New England Journal of Medicine in 2021 found Wegovy users who reduced their calorie intake and exercised regularly lost an average of 14.9% of their body weight over 68 weeks, much more than the 2.4% weight loss a placebo group recorded