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Whilst the pathogenesis of PD remains unclear, impaired insulin signaling appears detrimental in the development and progression of PD-related neurodegeneration

10.1073/pnas.0806720106 78 LockieS

Hindawi Limited Zander M, Madsbad S, Madsen JL, Holst JJ (2002) Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and -cell function in type 2 diabetes: a parallel-group study

both exenatide and metformin had similar effects on microvascular endothelial function measured by the reactive hyperemic index (RHI), as well as levels of inflammatory and oxidative stress markers including C-reactive protein (CRP), oxidized LDL (oxLDL), and vascular cell adhesion molecule-1 (VCAM-1) levels [63]

Abbreviations List: Funding No funding has been received for this manuscript Conflicts of Interest The author declares no conflict of interest References 1.Ogurtsova K., da Rocha Fernandes J.D., Huang Y., Linnenkamp U., Guariguata L., Cho N.H., Cavan D., Shaw J.E., Makaroff L.E