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That is over a decade of real-world safety data across millions of patients

However, excessive or sustained activation of mTORC1, reflected by elevated p-S6 levels, has been linked to impaired suppressive function and reduced lineage stability (71)

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Surgical guidelines recommend discontinuing these medications 24-48 hours preoperatively to reduce complication risk and ensure safer anesthetic management during the procedure

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Lee YJ, Wang H, Starrett GJ, Phuong V, Jameson SC, Hogquist KA