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Ann Endocrinol (Paris)

Among the 58% of adults who say they want to lose weight, nearly one-third (32%) expect to start a prescription GLP-1 drug in 2026, which translates to an estimated 48 million American adults including 9% who say they definitely will and 23% who say they probably will

In our study, the most treatment-persistent individuals after 1 and 2 years of follow-up were those in the insulin group (89.8% and 77.2%, respectively)

For example, the RNA sequencing analysis on isolated enteroendocrine cells from obese individuals with or without T2DM revealed decreased expression of the PCSK1 gene in the jejunal epithelium, contributing to the biosynthesis of GLP-1 [32]

GLP-1 is an incretin hormone that is secreted in response to food intake, and it exerts multiple actions conducive to glycemic control, including enhancing glucose-dependent insulin secretion, suppressing glucagon release, and delaying gastric emptying [39]

Buyer Takeaway: GLP-1 medications are clinically substantiated for weight management in appropriate candidates, but they require medical evaluation precisely because the contraindications and side effect profile are real