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In a clinical trial involving obese individuals with knee osteoarthritis, semaglutide was associated with a greater improvement in an osteoarthritis index score

Weight management The pronounced weight loss seen in clinical trials and post-marketing surveillance of GLP-1RAs led to early interest in their use for treatment of obesity in populations without diabetes.[27] Obesity is defined by the World Health Organization as a multifactorial chronic condition involving excess fat deposits and potentially impairing health

7 Safety considerations and patient selection GLP-1 receptor agonists have a well-defined safety profile

We can't stress this enough: your entire study relies on the molecular integrity of your reagents

TRIUMPH-2 (obesity in type 2 diabetes) adds to it later in 2026

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