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An important feature of GLP-1 RA use in type 2 diabetes is weight loss, which reduces insulin resistance and typically reaches a plateau after around 6 months of treatment
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Henriksen DB, Alexandersen P, Bjarnason NH, Vilsbll T, Hartmann B, Henriksen EE, et al

Clinically, these findings should be considered when treating patients with DPP-4i, especially in those patients with HF

It will come down to developing a strategy, then choosing what we think are the right targets, designing stable molecules, running the studies, and having the discipline to stop if its not working

10.1038/s41580-020-00317-7 16 CantiniG.MannucciE.LuconiM
