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The H2FPEF score and updated ESC guidelines have improved diagnostic precision by integrating clinical and echocardiographic parameters, yet many patients remain undiagnosed until advanced stages [1,31]

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At the 12 mg dose in the phase 2 trial, adults with type 2 diabetes achieved approximately 16.9% mean body weight reduction and around 2.2 percentage point HbA1c reduction at 24 weeks

The Royal College of Psychiatrists emphasises that body image concerns warrant psychological intervention rather than metabolic manipulation