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Probiotics and Type 1 Diabetes: An Interesting Connection A clinical trial on people with type 1 diabetes showed promising results using a probiotic blend ( Bifidobacterium longum , Lactobacillus bulgaricus , Streptococcus thermophilus ) over 12 weeks: Improved fasting blood sugar Reduced post-meal glucose spikes Better overnight stability And this was all without changing their insulin dose, suggesting that the gut flora itself helped balance blood sugar

Diabetes is a progressive condition, and discontinuing effective glucose-lowering therapy typically results in deterioration of glycemic control

Drugs used off label to treat raised ICP also have cognitive side effects, underscoring the unmet need for effective therapeutics which reduce ICP without worsening cognition

In human monocytes GLP-1 is strongly detectable, with waning after differentiation into macrophages ( The potential relationship between anti-inflammatory effects of GLP-1 and CAD is shown in Figure 1

Employers can stay ahead of the GLP-1 curve by proactively evaluating coverage strategies and vendors, monitoring utilization trends, and leveraging data-driven insights to manage costs effectively in 2025 and beyond.

Side effects were mainly mild-to moderate gastro-intestinal symptoms (nausea, vomiting, diarrhoea) mostly occurring with higher doses of retatrutide and with faster titration (Table 2)