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A novel triple receptor agonist conferred weight loss of up to 28.7% at 68 weeks and reductions in pain for adults with overweight or obesity and knee osteoarthritis, according to topline results from the TRIUMPH-4 trial

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Weight gain during semaglutide treatment is uncommon but possible, often linked to dosing adjustments, medication tolerance, or individual metabolic responses

A phase 2 trial finds that combining semaglutide with bimagrumab leads to greater weight loss while preserving lean mass, highlighting the importance of body composition in obesity treatment.

Currently, the anti-obesity medications that have been approved by the FDA for chronic weight management are orlistat, phentermine/topiramate, naltrexone/bupropion, and liraglutide