are glp 1 drugs safe long term GLP-1 Agonists: Using Semaglutide, Tirzepatide, and Orforglipron for Weight Loss and Obesity GLP-1 Medications: Separating Fact from

Ten-year follow-up in sleep AHEAD

SUSTAIN-6, trial to evaluate cardiovascular and other long-term outcomes with semaglutide in subjects with type 2 diabetes

However, evidence on the cardiovascular benefits of tirzepatide is only emerging and no randomized study has directly compared it to semaglutide 16,17

Malm-Erjeflt M, Bjrnsdottir I, Vanggaard J, et al

Tuttle K.R, Lakshmanan M.C, Rayner B., Busch R.S, Zimmermann A.G, Woodward DB., Botros F.T 2018

Nachnani et al (79) in a study in rats reported animals receiving exenatide for 75 days showed more acinar inflammation and pyknotic nuclei and these animals weighed less