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Areas to be covered in this Research Topic may include, but are not limited to: - Studies on the effect of SGLT2 inhibitors or GLP-1 receptor agonists on testosterone and gonadotropins in male patients with diabetes mellitus and hypogonadism - Studies on the effect of SGLT2 inhibitors or GLP-1 receptor agonists on testosterone gonadotropins in female patients with diabetes mellitus and polycystic ovary syndrome - Studies on the effect of SGLT2 inhibitors or GLP-1 receptor agonists on reninangiotensinaldosterone system in patients with diabetes mellitus and arterial hypertension - Studies on the effect of SGLT2 inhibitors or GLP-1 receptor agonists on Growth Hormone/IGF axis in patients with diabetes mellitus In patients with diabetes mellitus not achieving targets on lifestyle measures, pharmacologic therapy should be considered

Clinical trials for semaglutide show that digestive issues are common as the body adjusts to the dosage

Adler AI, Ting S, Dent R, Latimer N (2019) NICE guidance on dapagliflozin with insulin for type 1 diabetes

This assay is a Sandwich ELISA based, sequentially, on: 1) capture of GLP-1 Total molecules from samples to the wells of a microtiter plate coated by a pre-titered amount of anti- GLP-1 polyclonal antibody, 2) wash away of unbound materials from samples, 3) binding of a biotinylated anti- GLP-1 monoclonal antibody to the captured molecules, 4) wash away of unbound materials from samples, 5) conjugation of horseradish peroxidase to the immobilized biotinylated antibodies, 6) wash away of free enzyme conjugates, and 7) quantification of immobilized antibody-enzyme conjugates by monitoring horseradish peroxidase activities in the presence of the substrate 3,3,5,5-tetramethylbenzidine