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3.3 The mechanistic GLP-1/GIP/GCG receptors triple agonists in MASLD 3.3.1 Metabolic effects The development of triple receptor agonists targeting GLP-1, GIP, and GCG receptors represents a promising advancement in the treatment of MASLD

Who Is Most at Risk Not every patient on a GLP-1 faces the same level of skeletal risk

Their number and function are highly sensitive to oxidative stress, glycation end products, and inflammation (44)

The key principles: enough protein, enough fiber, enough water, avoid trigger foods that worsen GI side effects

The TRIUMPH-4 trial revealed a notable incidence of dysesthesia, an abnormal sensation affecting touch perception that can cause numbness, tingling, or unusual skin sensitivity

Ozempic, initially intended for diabetes management, is typically given at lower doses to control blood sugar levels in type 2 diabetics