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Clinical Frameworks: Defining Obesity Beyond Body Mass Index (BMI) An important milestone of 2025 was the publication of The Lancet Diabetes & Endocrinology Commission on the Definition and Diagnostic Criteria of Clinical Obesity

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While peptide drugs have a wide range of therapeutic applications, their relatively short half-life has been a challenge, attributed to poor metabolic stability and a fluid dynamic radius below the glomerular filtration limit of the kidneys.