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Materials and methods This systematic review and meta-analysis was written according to the 2020 Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines [8]

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The SSA also considers whether your condition has improved with treatment or whether your limitations continue despite following your treatment plan

Discontinuation due to side effects typically ranges 26% across agents, suggesting most adverse events are manageable rather than prohibitive

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and the University of Iowa Center for Hypertension Research