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In the US, aside from phentermine and orlistat, approved by the Food and Drug Administration (FDA) in 1959 and 1999, respectively, phentermine/topiramate extended release (Qsymia ) was approved in 2012

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SynonymsColchicine, Hyoscine, Scopolamine, and Strychnine

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GLP-1RA Cardiovascular Disease Outcomes Starting in 2008, the FDA began requiring all medications indicated for treatment of type 2 diabetes to evaluate cardiovascular risk reduction [45]

"GI AEs typically occur during initiation and uptitration, appearing as transient, mild-to-moderate symptoms." Laura Schalliol, PharmD, BCACP, BCGP, Professor of Pharmacy Practice In fact, 94% of adverse events reported in major clinical trials were mild or moderate in severity