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I think that jury is still out. Its possible that GLP-1s are affecting the brain and body in ways that researchers dont yet fully understand

Retatrutide is being studied for: Type 2 diabetes MASH(Metabolic Dysfunction-Associated Steatohepatitis), a liver condition caused by fat buildup Heart disease risk reduction Knee osteoarthritis in people with higher body weight More research is needed before doctors know whether retatrutide is safe and effective for these conditions

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247 Mechanistically, it is unclear how GLP-1-based therapies exert beneficial effects on the cardiovascular system, but studies have suggested that this is achieved by direct (cardiovascular GLP-1R activation) and indirect (promotion of the incretin effect) mechanisms

In: Goodman & Gilman's The Pharmacological Basis of Therapeutics

Before using semaglutide, wash your hands with soap and water