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Interestingly, Cav-1 directly interacts with DPP-IV by binding to its serine catalytic site (53, 54)

However, these recommendations lack sufficient evaluation of the risk-benefit profile in HS-specific populations, thereby justifying further safety studies

Cardiovascular benefits have been demonstrated in clinical trials for specific GLP-1 receptor agonists, with liraglutide, semaglutide, and dulaglutide showing reductions in major adverse cardiovascular events in patients with established cardiovascular disease or high cardiovascular risk

26,27 A Phase II trial in T2D showed a 1% reduction in HbA1c (Diabetes Control and Complications Trial units) and approximately 1.7% body weight reduction over 12 weeks, in comparison to placebo, but a further comparison to an open-label liraglutide active treatment control group was less impressive

Conclusion Ozempic has become a popular choice for endurance athletes who want to maximize their performance