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[DOI] [PMC free article] [PubMed] [Google Scholar] 77.Paddon-Jones D., Westman E., Mattes R.D., Wolfe R.R., Astrup A., Westerterp-Plantenga M

GLP-1 has also been shown to regulate colonic expression of angiotensin-converting enzyme (ACE) 2, 68 higher expression of which has been associated with more severe IBD phenotypes, 69 and modulation of this axis may benefit patients with IBD

doi:10.1016/j.lfs.2019.116566 128

These include: Gallstones and gallbladder issues, thought to be caused by rapid weight loss Pancreatitis studies have shown a higher risk for this condition while taking GLP-1 medications compared to other weight loss medications Gastroparesis (delayed stomach emptying) though these medications are designed to slow down digestion, if it slows down too much, it can lead to other symptoms and complications

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