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Depression of insulin release by anti-GIP serum after oral glucose in rats

Pharmaceuticals (Basel) 2023;16:994

Beyond that, a head-to-head comparison from the SURMOUNT-5 trial illustrates the difference clearly: Participants taking tirzepatide lost an average of 20.2% of their body weight compared to 13.7% with semaglutide

[PubMed] [Google Scholar] 16.Mojsov S, Heinrich G, Wilson IB, Ravazzola M, Orci L, Habener JF

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This side effect has not been reported at similar rates with semaglutide or tirzepatide and appears to be related to the glucagon receptor activation component unique to retatrutide