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Description
120(1): p

Endogenously, GLP-1 is secreted by intestinal L cells in response to food, and has multiple roles: enhancing insulin secretion (in a glucose-dependent way), reducing glucagon secretion, slowing gastric emptying, increasing feelings of fullness/satiety, and improving glucose disposal in peripheral tissues

, Glucagon-Like Peptide-1 Receptor Agonists and Liver Outcomes in Patients With MASLD and Type 2 Diabetes, Alimentary Pharmacology & Therapeutics 61, no

Hormonal Synergy with Leptin GLP-1 restores leptin sensitivity, enabling the brain to accurately sense energy stores

This was demonstrated in two randomised controlled trials (RCTs) that showed a decrease in epicardial adipose tissue in patients with T2D and obesity on liraglutide and exenatide according to echocardiography and cardiac MRI

Furthermore, significant weight loss can tend to lead to complications that require cosmetic surgery such as abdominoplasty, breast reduction/augmentation and gluteal lifts to name a few
