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The behavioral consequence of this circuit is well-documented: optogenetic stimulation of VTA GABA neurons directly suppresses the activity and excitability of neighboring DA neurons [48] and, critically, this suppression disrupts reward consumption while leaving anticipatory behavior intact [49]

Leonard Glass, senior vice president of global medical affairs at Lilly Cardiometabolic Health, said in a statement

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Children with this mutation tend to develop early-onset obesity

The two forms work similarly and have comparable results, but differ in dosing, absorption, and regimens

Rapid weight loss often leads to rebound weight gain, while steady loss is more likely to last