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Conclusion GLP-1 receptor agonists have emerged as revolutionary therapeutic agents in the treatment of T2DM and obesity, exhibiting significant effectiveness via their multi-faceted activities

doi: 10.1124/mol.111.074757

doi: 10.1136/bmj.l4898 7 TanZHuangSMeiKLiuMMaJJiangYet al

Gut microorganisms that produce short-chain fatty acids stimulate cells in the colon lining to produce GLP-1 and other hormones

While its expression is most concentrated in these areas, it is also present in the lungs, heart, kidneys, digestive system, liver, skeletal muscles, and peripheral nervous system to a lesser extent [27, 28] (Fig

However, it acts in contrast with GLP-1 as much as glucagon release is concerned by enhancing its release