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Weight loss can vary widely among individuals, but many people lose between 5% to 10% of their body weight over six months to a year

and anyone with a rectal or abdominal mass

Guanylate cyclase-C agonist laxatives: Certain drugs both increase water in the gastrointestinal tract and make the stool move through the colon faster

C., Goldbach, H

Historical Relevance Image 5 (Source) As mentioned before, the most historically-relevant link to gila monster venom comes in the GLP-1 drug class for treatment of type-2 diabetes mellitus as well as obesity

Understanding this link is paramount for any laboratory looking to isolate mechanisms of action or explore the long-term safety profile of tri-agonists