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10.1016/j.drudis.2016.01.016 [DOI] [PMC free article] [PubMed] [Google Scholar] Gimeno D., Kivimaki M., Brunner E

The oral formulation of Rybelsus incorporates an absorption enhancer (sodium N-(8-[2-hydroxybenzoyl] amino) caprylate, or SNAC) to facilitate semaglutide absorption across the gastric mucosa, overcoming the challenges of delivering a peptide drug orally

However, the potential of this drug class was turbocharged by the FDAs December 2017 approval of Novo Nordisks weekly injectable Ozempic (semaglutide) and May 2018 approval of Eli Lillys dual agonist Mounjaro (tirzepatide), both for type 2 diabetes

Girish PJ, Abdelmalak BB, Weigal WA, et al

That meant no dangerous sugar crashes, a common problem with some older diabetes drugs