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Patients should follow provider guidance closely and report persistent or severe side effects

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In diabetes care, GLP-1 receptor agonists are typically introduced as part of a stepwise treatment strategy

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OA-induced GPR-120-knockout mice showed accelerated OA progression as compared with OA wild-type mice

Like the rat, LiCl activates PPG-neurons, induces anorexia, and CTA formation in wild-type mice, but LiCl does not evoke aversive effects in mice lacking GLP-1Rs, indicating species differences [176]