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OGTTs have also been used for long-term follow-up studies 6

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Consequently, the potential for unpublished studies with null or negative results to influence our findings cannot be ruled out

The prolong use of certain gut peptides such as PYY3-36 and GLP-1, seems to be rational, particularly, that the deficiency of these peptides in obesity has been documented (95)

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[16] DPP-4 inhibitors (such as sitagliptin), which enhance incretin activity through a different mechanism Insulin therapy, particularly if oral agents and other injectables are unsuitable Traditional agents like metformin, sulphonylureas, or pioglitazone, depending on individual circumstances NICE guideline NG28 recommends individualised treatment approaches based on HbA1c targets, cardiovascular risk, renal function, and patient preferences