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Attention to abdominal fat distribution is particularly relevant for identifying those people who, despite being of normal weight, have increased waist circumference values and are therefore considered living with metabolically obesity or rather burdened with cardio-metabolic complications [3]

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Derived from hormone-related peptide frameworks, it has been examined for its effects on multi-receptor metabolic signaling processes involving GLP-1, GIP, and glucagon receptor pathways

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We next assayed cAMP-dependent protein kinase (PKA) (27, 35), ERK (36), and eNOS (37) activations as putative downstream targets of GLP-1(2836)induced cAMP and/or molecules known to be involved in GLP-1mediated cytoprotection (21)

Glucagon-like peptide-1 inhibits LPS-induced IL-1beta production in cultured rat astrocytes