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Healthy Weight Loss Maintenance with Exercise, GLP-1 Receptor Agonist, or Both Combined Followed by a Year without Treatment: A Post-Treatment Analysis of a Randomised Placebo-Controlled Trial

Zhang W, Qu W, Wang H

34 , 35 However, the controversy surrounding the possible benefits of GIPR agonism stems from two main observations: its impaired insulinotropic effects, 36 , 37 and the prevention of weight gain by suppression of endogenous GIP-induced adipogenesis, 38 , 39 However, these seemingly discouraging observations have been questioned by the finding of the central anorexic effects of GIP, 4042 and benefits of the GLP-1R/GIPR dual agonist LY3298176 (tirzepatide) in diabetic and overweight individuals

The remaining 158,349 patients who did not use GLP-1 RAs were enrolled as the GLP-1 RAs non-users group

P =0.07), meningioma (RR, 0.62

But others, like the positive impacts we are seeing for individuals who have an alcohol addiction, may point to other impacts of these drugs