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Without intentional high-protein meals, you lose lean muscle mass alongside fat which slows metabolism, changes body composition, and makes it harder to maintain results long-term

They also flag that the dataset they used contains predominantly older white males, so analysis in a more diverse cohort would be useful

FDA Approval Timeline As of mid-2025, Retatrutide is: Still under investigation in phase 3 clinical trials Expected to complete primary trials by late 2025 Anticipated to receive FDA approval in 2026 Until then, it is available only for research purposes , and should not be used outside of controlled clinical settings without professional supervision