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Canadian Geriatrics Journal 25(3):254-261

Patients who reduce their dose without medical guidance risk losing progress or increasing their long-term health risks

While no specific guidelines exist for MC4R -deficient patients, extrapolating from osteoporosis management principles suggests that baseline dual-energy X-ray absorptiometry (DXA) assessment may be reasonable in individuals with additional fracture risk factors or those anticipating substantial and sustained weight loss [72]

"For folks that are coming in getting these medications because they want to lose a quick 10 to 15 pounds or it's not clinically appropriate for them, it cuts down supply, and currently supply is an issue and the cost is also an issue," said Hemalee Patel, DO, senior medical director for chronic care management at One Medical

Cognitive improvements were happening in week 2-3

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