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Description
doi:10.1056/NEJMoa1901118
Semaglutide is a glucagon-like peptide 1 (GLP-1) receptor agonist used to improve blood sugar control in adults with type 2 diabetes
The molecular design principles that enable this extended half-lifeincluding the C18 fatty acid chain, which confers strong albumin binding, and amino acid substitutions that confer DPP-4 resistancewere elucidated during the development of semaglutide (Lau et al., 2015)
The proportions in the STEP program were 0% to 0.2%
10.1053/j.gastro.2016.12.052 [DOI] [PMC free article] [PubMed] [Google Scholar] 22
Persistent vomiting, dehydration, or inability to maintain adequate oral intake whilst on GLP-1 therapy requires prompt medical review
