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When intestinal flora dysbiosis occurs, metabolic disorders will occur, the permeability of the intestinal tract will increase and a large amount of intestinal bacterial metabolites, bacterial components and other harmful substances will enter the liver through the portal vein via the intestinal-hepatic axis and through the enterohepatic circulation reach the liver and bind to the TLR4 of hepatocytes and exacerbate the hepatic inflammatory response, oxidative stress and lipid accumulation, which further stimulate the inflammatory response

And year after year, many people feel trapped in a cycle of ineffective methods

At the moment, the use of such drugs is almost exclusively limited to people with a clear medical need to lose weight

Clinical trial data present a nuanced picture

Its not happening in isolation. Yet some practitioners are more reluctant for semaglutide to be used at all