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The key limitations of the extension were the relatively small sample size compared with the main STEP 1 trial population and the selection of sites based on those with the highest recruitment in the STEP 1 main phase, which could introduce an element of selection bias

Jun 18 2021;22(12)doi:10.3390/ijms22126541 Tasic N, Jakovljevic VLJ, Mitrovic M, et al

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We present a detailed picture showing that epithelial-to-mesenchymal transition, cancer metabolic reprogramming, alterations in important signalling pathways, epigenetic aberrations and the tumour microenvironment are crucial drivers of PTC metastasis