why does glp-1 cause muscle loss Loss: The Fear Is Overblown Muscle loss and GLP-1R agonists

In particular, the studies only enlisted people who previously failed dieting and also recruited people at the 95th percentile for BMI

Eli Lilly's Foundayo, a daily weight-loss pill, as well as Zepbound KwikPen, a weekly weight-loss injection, are covered, along with Novo Nordisk's Wegovy weight-loss medication in both injection and pill forms

The initial pivotal studies that led to the first wave of GLP-1 RAs demonstrated that they work in several ways, including stimulating insulin release, slowing digestion, reducing appetite, and inhibiting glucagon release

FDA-approved prescribing information for all GLP-1 medications specifies incremental dose increases over weeks to months

doi: 10.1210/endo.139.9.6202

Summary: GLP-1 medications do not directly cause muscle loss, but the substantial weight reduction they facilitate results in some lean body mass loss, similar to other weight loss methods