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The TRIUMPH-4 Phase 3 readout in April 2026 extended that to 28.7% at 68 weeks in a population with knee osteoarthritis - a patient group in whom weight loss produces disproportionate benefit on a secondary outcome (pain) the trial measured and reported as a 75.8% reduction on the WOMAC pain index

p = 0.48)

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The anti-inflammatory and antifibrotic effects of GLP-1 RAs further reinforce their therapeutic potential in NASH

GLP-1 projections are neuroanatomically positioned to influence both subregions, since GLP-1R and innervating fibers can be found in both the shell and the core

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