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Open 5 , e2235003 (2022)

The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity

Many patients abandon the drug in a matter of months, due to cost, availability, and side effects

These compounds facilitate weight loss by assisting the livers breakdown of fats

Step 2: Consider Zepbound if Seeking Weight Loss If you want tirzepatide for weight loss and dont have a diabetes diagnosis, Zepbound may be easier to get covered by insurance (since its FDA-approved for that purpose) and offers better self-pay pricing through LillyDirect ($349 to $499 versus $1,000+ for Mounjaro)