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Colonizing Lactobacillus reuteri and Bacteroides thetaiotaomicron in microbiota-deficient mice suppressed GLP-1 levels and restored the hypolocomotor phenotype

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The trial protocol did not specify a particular time of day for injections, which is itself an informative data point

Flat-knit compression stockings are preferred due to their higher bending stiffness, allowing better support of deep tissue folds without constriction, and are more comfortable.3,24 Compression therapy should be tailored to disease stage and individual tolerance

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In contrast, the trial product estimand assessed treatment effects under the assumption that patients received the study drug for the duration of the trial and did not receive any additional anti-diabetic medications, aiming to reflect the effects of the study medications without the confounding effects of rescue medication or any other changes in glucose-lowering medication [28]