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These are modest changes that most people never notice without a heart rate monitor
The Novel Long Acting GLP-1/Glucagon Dual Agonist HM12525A Reduces Body Weight and Improves Glycermic Control in Rodent Models
Retrieved from: FDA

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For example, co-morbid conditions like hyperlipidemia could tip the scale and make one drug more suitable for a specific patient

Prescribing Information: Metformin ER