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Wegovy may also cause side effects, such as : Headache Fatigue Indigestion Heartburn (gastroesophageal reflux disease) Dizziness Bloating Belching Flatulence Low blood sugar (hypoglycemia) in people with type 2 diabetes Some of these effects are more common than others

Showalter, D.B

However, the effects of combinations of multi-receptor agonists in humans can be challenging to predict from animal studies [68]

GLP-1 drugs are not recommended for people with a personal or family history of medullary thyroid cancer or multiple endocrine neoplasia 2A or 2B

Common side effects are gastrointestinal-related and include nausea, vomiting, diarrhea, decreased appetite, constipation, upper abdominal discomfort, and abdominal pain

Notably, in the SELECT trial, individuals with obesity with established ASCVD without T2D were treated with semaglutide 2.4 mg/week and demonstrated a weight loss of over 9% (59)