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One issue to be solved may be the differential expression patterns of SGLT-2 in CNS between human and rodents, although some studies have attempted to describe central distribution and the related function

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Conclusions High cost or insurancerelated issues are the most common reasons for treatment discontinuation with semaglutide or tirzepatide for obesity

10.1038/ijo.2015.172 [DOI] [PubMed] [Google Scholar] Steinert, R